Joost Kluiver
dr.
I have a central role in all research projects focusing on the role of noncoding RNAs. My main aim is to understanding how small and long non-coding RNAs contribute to the pathogenesis of B-cell lymphoma. Ongoing studies include MYC-regulated miRNAs and lncRNAs, as well as miRNA-lncRNA interactions and the role of circular RNAs. We apply state-of-the-art methodology including AGO2-RIP, RNA-FISH and gain- and loss-of-function screens using shRNA and CRISPR-Cas technology.
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(87)
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(27)
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(11)
Analysis of serum immune markers in seropositive and seronegative rheumatoid arthritis and in high-risk seropositive arthralgia patients
Published in: Scientific Reports
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10.1038/srep26021
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Presence of autoantibodies precedes development of seropositive rheumatoid arthritis (SP RA) and seropositive arthralgia patients (SAP) are at risk of developing RA. The aims of the study are to identify additional serum immune markers discriminating between SP and seronegative (SN) RA, and markers identifying high-risk SAP. Sera from SAP (n = 27), SP RA (n = 22), SN RA (n = 11) and healthy controls (n = 20) were analyzed using the Human Cytokine 25-Plex Panel. Selected markers were validated in independent cohorts of SP RA (n =...
Paulina Chalan, Johan Bijzet, Anke van den Berg, Joost Kluiver, Bart-Jan Kroesen, Annemieke M. H. Boots, Elisabeth Brouwer
Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma
Published in: Oncotarget
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10.18632/oncotarget.6165
document
Several studies have indicated an important role for miR-155 in the pathogenesis of B-cell lymphoma. Highly elevated levels of miR-155 were indeed observed in most B-cell lymphomas with the exception of Burkitt lymphoma (BL). However, the molecular mechanisms that underlie the oncogenic role of miR-155 in B-cell lymphoma are not well understood. To identify the miR-155 targets relevant for B-cell lymphoma, we performed RNA immunoprecipitation of Argonaute 2 in Hodgkin lymphoma (HL) cells upon miR-155 inhibition and in BL cells upon ectopic expression of miR-155. We identified 54...
Joost Kluiver, Izabella Slezak-Prochazka, Debora de Jong, Katarzyna Smigielska, Gertrud Kortman, Melanie Winkle, Bea Rutgers, Jasper Koerts, Lydia Visser, Arjan Diepstra, Bart-Jan Kroesen, Anke van den Berg
Transforming Growth Factor Beta Affects Mirna Expression In Control And COPD Fibroblasts
J. Ong, W. Timens, V. Rajendran, A. Algra, A. Spira, M. Lenburg, J. Campbell, D. S. Postma, A. Van den Berg, J. Kluiver, Corry-Anke Brandsma
Mir-155 Enhances B-Cell Lymphoma Growth By Targeting TBRG1
Joost Kluiver, Izabella Slezak, Melanie Winkle, Lydia Visser, Arjan Diepstra, Bart-Jan Kroesen, Anke Van den Berg
KNOWN AND NOVEL MICRORNA EXPRESSION PROFILES IN BRCA1-ASSOCIATED PELVIC HIGH-GRADE SEROUS CANCER
J. Brouwer, R. C. de Almeida, J. Kluiver, W. Reitsma, R. Modderman, S. Withoff, H. Hollema, G. H. de Bock, M. J. E. Mourits, Anke Berg, van den