Arjan Diepstra
dr.
As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.
Latest publications
(215)
Activities
(38)
Press/Media
(6)
Prizes
(4)
Datasets
(1)
Supervised work
(11)
Clues for disease progression at time of diagnosis in patients with primary cutaneous follicle center lymphoma
Anne M. R. Schrader, Ruben A. L. de Groen, Rein Willemze, Patty M. Jansen, Koen D. Quint, Tom van Wezel, Ronald van Eijk, Dina Ruano, Arjan Diepstra, Anke van den Berg, Naomi Kakiailatu, Maarten H. Vermeer, Joost S. P. Vermaat
Aberrant Expression of and Cell Death Induction by Engagement of the MHC-II Chaperone CD74 in Anaplastic Large Cell Lymphoma (ALCL)
Published in: Cancers
Access to document
10.3390/cancers13195012
document
Simple Summary: Anaplastic large cell lymphoma (ALCL) is a lymphoid malignancy considered to be derived from T cells. Currently, two types of systemic ALCL are distinguished: anaplastic lymphoma kinase (ALK)-positive and ALK-negative ALCL. Although ALK(+) and ALK(-) ALCL differ at the genomic and molecular levels, various key biological and molecular features are highly similar between both entities. We have developed the concept that both ALCL entities share a common principle of pathogenesis. In support of this concept, we here describe a common deregulation of CD74, which is usually...
Kathrin D Wurster, Mariantonia Costanza, Stephan Kreher, Selina Glaser, Björn Lamprecht, Nikolai Schleussner, Ioannis Anagnostopoulos, Michael Hummel, Korinna Jöhrens, Harald Stein, Arturo Molina, Arjan Diepstra, Bernd Gillissen, Karl Köchert, Reiner Siebert, Olaf Merkel, Lukas Kenner, Martin Janz, Stephan Mathas
Peripheral blood cytopenias in the aging general population and risk of incident hematological disease and mortality
Published in: Blood
Access to document
10.1182/bloodadvances.2021004355
document
Peripheral blood cytopenias may precede the development of hematological malignancies and frequently pose clinical challenges in the older population. The natural course of (mild) cytopenias during aging and their association with hematological disorders in community-dwelling individuals are not well studied. Within the population-based Lifelines cohort (n = 167 729), we studied changes in peripheral blood counts, occurrence of cytopenias, and associated hematological outcomes in the context of aging. Development of hematological malignancies and (cause-specific) mortality were evaluated by linkage to nationwide registries. Anemia and thrombocytopenia emerged with older...
Isabelle A van Zeventer, Aniek O de Graaf, Melanie M van der Klauw, Edo Vellenga, Bert A van der Reijden, Jan Jacob Schuringa, Arjan Diepstra, Luca Malcovati, Joop H Jansen, Gerwin Huls
TERMINAL COMPLEMENT ACTIVATION MAY NOT CONTRIBUTE TO ORGAN DAMAGE IN ANTIBODYMEDIATED REJECTION
Gesa Tiller, Rosa Lammerts, Jessy J. Karijosemito, Arjan Diepstra, Anita H. Meter, Marc Seelen, Marius van den Heuvel, Bouke Hepkema, Jaap van den Born, Stefan Berger
SUCCESSFUL SECONDARY TRANSPLANTATION AFTER PLASMAPHERESES FOR SUSPECTED ANTI-ENDOTHELIAL CELL ANTIBODIES
Rosa Lammerts, Magdalena Huberts, Mohamed Daha, Bouke Hepkema, Robert Pol, Arjan Diepstra, Jaap van den Born, Stefan Berger