Arjan Diepstra
dr.
As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.
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Supplementary Material for: MicroRNA High Throughput Loss-of-Function Screening Reveals an Oncogenic Role for miR-21-5p in Hodgkin Lymphoma
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10.6084/m9.figshare.7047695.v1
Background/Aims: Classical Hodgkin lymphoma (cHL) is among the most frequent lymphoma subtypes. The tumor cells originate from crippled germinal center (GC)-B cells that escaped from apoptosis. MicroRNAs (miRNAs) play important roles in B-cell maturation and aberrant expression of miRNAs contributes to the pathogenesis of cHL. Our aim was to identify oncogenic miRNAs relevant for growth of cHL using a high-throughput screening approach. Methods: A lentiviral pool of 63 miRNA inhibition constructs was used to identify miRNAs essential to cell growth in three cHL cell lines in duplicate. As...
Fubiao Niu (Contributor)Ye Yuan (Second Affiliated Hospital of Harbin Medical University) (Contributor)Maria Sarkis Azkanaz (Contributor)Arjan Diepstra (Contributor)Leo Bystrykh (Contributor)Lydia Visser (Contributor)Agnieszka Dzikiewicz-Krawczyk (Polish Academy of Sciences) (Contributor)Jan Osinga (Contributor)Bea Rutgers (Contributor)Klaas Kok (Contributor)Jasper Koerts (Contributor)Martijn Terpstra (Contributor)Joost Kluiver (Contributor)Anke van den Berg (Contributor)Ilja Nolte (Contributor)Debora de Jong (Contributor)