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Anke van den Berg
prof. dr.

I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.

The microenvironment in classical Hodgkin lymphoma: an actively shaped and essential tumor component
Published in: Seminars in cancer biology
Classical Hodgkin lymphoma (cHL) is characterized by a minority of tumor cells derived from germinal center B-cells and a vast majority of non-malignant reactive cells. The tumor cells show a loss of B-cell phenotype including lack of the B-cell receptor, which makes the tumor cells vulnerable to apoptosis. To overcome this threat, tumor cells and their precursors depend on anti-apoptotic and growth stimulating factors that are obtained via triggering of multiple membrane receptors. In addition, tumor cells shape the environment by producing a wide variety of chemokines and...
Yuxuan Liu, Ahmad Sattarzadeh, Arjan Diepstra, Lydia Visser, Anke van den Berg
Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma
Published in: PLoS ONE
The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL. IGF-1R was overexpressed in 55% (44/80) of cHL patients. Phosphorylated IGF-1R was detectable in a minority of the IGF-1R positive tumor cells. The overall survival (OS, 98%) and 5-year progression-free survival (PFS, 93%) was significantly higher in IGF-1R positive cHL patients compared to IGF-1R negative patients (OS 83%,...
GATA6 expression in Barrett’s metaplasia development and malignant progression
Kirill Pavlov, Judith Honing, Coby Meijer, Wytske Boersma-van Ek, Frans Peters, Anke van den Berg, Arend Karrenbeld, John Theodorus Plukker, Frank Kruyt, Jan Kleibeuker
Microenvironment, Cross-Talk, and Immune Escape Mechanisms: Hodgkin lymphoma
The role of microRNAs in B cell Hodgkin and non-Hodgkin lymphoma. 17th Gliwice Scientific Meetings (Gliwici, Poland)