Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
General Assembly, Diagnosis, Imaging: Proceedings of International Consensus on Orthopedic Infections
Published in: Journal of Arthroplasty
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10.1016/j.arth.2018.09.073
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Claudio Diaz-Ledezma, René Espinosa-Mendoza, Jiří Gallo, Andor Glaudemans, Felipe Gómez-García, Stuart Goodman, Milan Kaminek, Theo L.B. Le Roux, Adolfo Llinás, Eva Nieslanikova, Libuse Quinn, Peter Sculco, Michal Svoboda
FDG-PET/CT for Detecting an Infection Focus in Patients With Bloodstream Infection: Factors Affecting Diagnostic Yield
Published in: Clinical Nuclear Medicine
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10.1097/RLU.0000000000002381
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PURPOSE: To investigate the diagnostic performance of F-fluoro-2-deoxy-D-glucose (FDG) PET/ CT for the detection of an infection focus in patients with a bloodstream infection (BSI) and to identify factors influencing the diagnostic yield of FDG-PET/CT. METHODS: This retrospective single-center study included 185 consecutive patients with a BSI who underwent an FDG-PET/CT scan for the detection of an infection focus between 2010 and 2017. The final diagnosis at hospital discharge was used as reference standard. Diagnostic performance of FDG-PET/CT for the detection of an infection focus was assessed, and...
Role of FDG PET/CT in monitoring treatment response in patients with invasive fungal infections
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-018-4192-z
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INTRODUCTION: Invasive fungal infections (IFIs) occur mostly in immunosuppressed patients and can be life-threatening. Inadequate treatment is associated with high morbidity and mortality. We examined the role of 2-fluorodeoxyglucose positron emission tomography integrated with CT (FDG-PET/CT) in monitoring IFIs and therapy decision-making, and evaluated the role of baseline metabolic parameters in predicting the metabolic response. METHODS: All patients between October 2009 and March 2018, diagnosed with IFIs, treated with antifungal drugs, and who underwent FDG-PET/CT at baseline and at one or more timepoints during treatment were retrospectively included....
Alfred O Ankrah, Lambert F R Span, Hans C Klein, Pim A de Jong, Rudi A J O Dierckx, Thomas C Kwee, Mike M Sathekge, Andor W J M Glaudemans
Imaging cardiac innervation in amyloidosis
Published in: Journal of Nuclear Cardiology
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10.1007/s12350-017-1059-9
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Cardiac amyloidosis is a form of restrictive cardiomyopathy resulting in heart failure and potential risk on arrhythmia, due to amyloid infiltration of the nerve conduction system and the myocardial tissue. The prognosis in this progressive disease is poor, probably due the development of cardiac arrhythmias. Early detection of cardiac sympathetic innervation disturbances has become of major clinical interest, because its occurrence and severity limits the choice of treatment. The use of iodine-123 labelled metaiodobenzylguanidine ([I-123]MIBG), a chemical modified analogue of norepinephrine, is well established in patients with heart...
Incidental meningioma detected with [18F]-FDOPA PET/CT
Published in: European Journal of Hybrid Imaging
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10.1186/s41824-018-0041-3
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A 59 year old patient was referred to our department to detect disease activity related to clinical symptoms of tiredness, weight loss and an elevated serum serotonine, suspicious of a neuro-endocrine tumour. A 18F-fluoro-l-dihydroxy-phenylalanine (FDOPA) PET/CT scan was performed, which showed focally increased uptake in the terminal ileum and in a mesenterial lymph node. Additionally, an area of intense uptake was observed intracranially. Histological analysis confirmed the presence of a WHO grade I meningioma. Few cases of FDOPA PET uptake in meningiomas have been published, underlining it is...