Anke van den Berg
prof. dr.
I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.
A NEW RFLP IDENTIFIED AT THE D3S48 LOCUS
K KOK, MZ FAN, A JONAS, Anke van den Berg, B CARRITT, CHCM BUYS
PARTIAL 3Q DUPLICATION SYNDROME AND ASSIGNMENT OF D3S5 TO 3Q25-3Q28
We report a girl with a de novo duplication of the distal part of the long arm of chromosome 3 and review the literature. Our patient had the facial characteristics and many other anomalies of the partial 3q duplication syndrome. As a hitherto undescribed symptom in partial 3q trisomy syndrome, she had microphthalmia. The karyotype of this girl was interpreted as an inverse duplication of the terminal portion of chromosome 3: 46,XX,inv dup (3)(pter-q28::q28-q25::q28-qter). Quantitative hybridisation studies with 3p and 3q probes gave a consistent 3:2 ratio of...
Linkage Analysis of Families With Hereditary Retinoblastoma: Nonpenetrance of Mutation, Revealed by Combined Use of Markers Within and Flanking the RB1 Gene
Nonpenetrance of the inherited mutation responsible for retinoblastoma has been reported. By DNA analysis in families with hereditary retinoblastoma, it is possible to identify healthy individuals in whom the mutation is nonpenetrant. This requires the use of DNA markers both within and flanking the retinoblastoma gene. We have analyzed the segregation of several markers in 19 families (69 meioses) with hereditary retinoblastoma. In two families a carrier was identified who showed nonpenetrance of the mutation predisposing to retinoblastoma. The intragenic markers were informative in 15 pedigrees. The use...
H Scheffer, G.J. te Meerman, Y.C.M Kruize, A.H.M van den Berg, D.P Penninga, K.E.W.P Tan, D.J der Kinderen, C.H.C.M Buys
LOSS OF HETEROZYGOSITY IN A GENE CODING FOR A THYROID-HORMONE RECEPTOR IN LUNG CANCERS
F LEDUC, H BRAUCH, C HAJJ, A DOBROVIC, F KAYE, A GAZDAR, JW HARBOUR, OS PETTENGILL, GD SORENSON, Anke van den Berg, K KOK, B CAMPLING, F PAQUIN, WEC BRADLEY, B ZBAR, J MINNA, C BUYS, J AYOUB
DIRECT MOLECULAR ANALYSIS OF A DELETION OF 3P IN TUMORS FROM PATIENTS WITH SPORADIC RENAL-CELL CARCINOMA
AH VANDERHOUT, K KOK, Anke van den Berg, JW OOSTERHUIS, B CARRITT, CHCM BUYS