Anke van den Berg
prof. dr.
I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.
An 80 Kb P1 clone from chromosome 3p21.3 suppresses tumor growth in vivo
High frequencies of allelic loss on the short arm of chromosome 3 in small cell lung cancer (SCLC) and a number of other tumors suggest the existence of a tumor suppressor gene(s) within the deleted regions. Two small cell lung cancer lines, NCI H740 and GLC20, have been described which have homozygous deletions in the region 3p21.3. The deleted region overlaps with a 2 Mb fragment of human DNA present in the interspecies hybrid HA(3)BB9F, that suppresses tumor formation by mouse A9 fibrosarcoma cells. Human sequences from this...
MC Todd, RH Xiang, DK Garcia, KE Kerbacher, SL Moore, CH Hensel, P Liu, MJ Siciliano, K Kok, Anke van den Berg, P Veldhuis, CHCM Buys, AM Killary, SL Naylor
Involvement of multiple loci on chromosome 3 in renal cell cancer development
Chromosomal findings and p53-mutation analysis in chromophilic renal-cell carcinomas
Published in: International Journal of Cancer
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10.1002/(SICI)1097-0215(19960927)68:1<47::AID-IJC9>3.0.CO;2-X
The chromosomal pattern of 31 specimens of chromophilic renal-cell cancer (RCC), selected according to the criteria mentioned in the classification of Thoenes and Storkel, is presented. A high male preponderance was found (8.7:1). Cytogenetic analysis revealed a typical pattern of numeric alterations specific for this sub-type in the majority of cases (i.e., -Y, +7, +12, +16, +17, and/or +20), which is different from the chromosomal patterns found in other sub-types of RCC. Gain of chromosome 20, as well as loss of the extra copy of chromosome 17 or...
Trijnie Dijkhuizen, Eva van den Berg , Anke van den Berg, S Storkel, B DeJong, G Seitz, W Henn
Extensive mutation scanning of RET in sporadic medullary thyroid carcinoma and of RET and VHL in sporadic pheochromocytoma reveals involvement of these genes in only a minority of cases
Published in: Journal of Clinical Endocrinology and Metabolism
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10.1210/jcem.81.8.8768845
Sporadic medullary thyroid carcinoma (MTC) and pheochromocytoma (PC) have been reported to be associated with some specific RET gene mutations. To assess the role of RET in the development of MTC and PC, we screened 14 sporadic MTC, two MTC-derived cell lines, and 5 sporadic PC cases for RET mutations by a systematic analysis of the whole coding sequence, including all intron-exon junctions. In only 6 of the 14 sporadic MTC we were able to detect a RET mutation. Apart from the Met(918)–>Thr mutation in 5 of the...
RMW Hofstra, T Stelwagen, RP Stulp, D DeJong, M Hulsbeek, E J Kamsteeg, Anke van den Berg, Rudolf Landsvater, A Vermey, WM Molenaar, C. J. M. Lips, CHCM Buys
Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer
Small cell lung cancer (SCLC) has been correlated with a deletion in the short arm of chromosome 3, with the region 3p21 being lost from one homolog in almost all cases. Two SCLC cell lines have homozygous deletions in 3p21, and these deletions overlap with a fragment of chromosome 3 that has tumor suppression activity in vivo. We have isolated some cDNA clones from this region that are homologous to the genes constituting the semaphorin family. They represent a novel human semaphorin, termed sema III/F (HGMW-approved symbol SEMA3F),...
RH Xiang, CH Hensel, DK Garcia, HC Carlson, K Kok, MC Daly, K Kerbacher, Anke van den Berg, P Veldhuis, CHCM Buys, SL Naylor