Arjan Diepstra
dr.
As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.
Latest publications
(216)
Activities
(38)
Press/Media
(7)
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(4)
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(1)
Supervised work
(12)
Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients: Results of the TransplantLines Biobank and Cohort Study
Published in: Kidney International Reports
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10.1016/j.ekir.2024.10.002
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Introduction: Muscles are crucial for daily activities, and kidney transplant recipients (KTRs) often have reduced muscle mass and strength. We aimed to investigate the potential relationship of muscle mass and strength with physical health-related quality of life (HRQoL) in KTRs. Methods: Data from the TransplantLines Biobank and Cohort Studies were used. Muscle mass was assessed using appendicular skeletal muscle mass index (ASMI) and 24-hour urinary creatinine excretion rate index (CERI). Muscle strength was assessed by handgrip strength index (HGSI). HRQoL was measured using Short Form 36 physical component...
TransplantLines Investigators, Tim J. Knobbe, Gijs M.M. Lenis, Dirk A.J. van der Vossen, Jory Wentink, Daan Kremer, Evelien E. Quint, Antonio W. Gomes-Neto, Robin P.F. Dullaart, Robert A. Pol, Stefan P. Berger, Casper F.M. Franssen, Stephan J.L. Bakker, Adrian Post
Standardization through education of molecular pathology: a spotlight on the European Masters in Molecular Pathology
Published in: Virchows Archiv
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10.1007/s00428-024-03933-2
Despite advancements in precision medicine, many cancer patients globally, particularly those in resource-constrained environments, face significant challenges in accessing high-quality molecular testing and targeted therapies. The considerable heterogeneity in molecular testing highlights the urgent need to harmonize practices across Europe and beyond, establishing a more standardized and consistent approach in MP laboratories. Professionals, especially molecular pathologists, must move beyond traditional education to cope with this heterogeneity. This perspective addresses critical issues in molecular pathology (MP), such as limited access to high-quality molecular testing, leading to disparities in cancer...
Marius Ilié, Vivien Lake, Enrique de Alava, Serena Bonin, Sandra Chlebowski, Aurélie Delort, Elisabeth Dequeker, Raed Al-Dieri, Arjan Diepstra, Olli Carpén, Catarina Eloy, Ambrogio Fassina, Falko Fend, Pedro L Fernandez, Gregor Gorkiewicz, Simon Heeke, Rui Henrique, Gerald Hoefler, Pablo Huertas, Michael HummelKarl Kashofer, Jeroen van der Laak, Rocio Martinez de Pablos, Fernando Schmitt, Ed Schuuring, Giorgio Stanta, Wim Timens, Benedikt Westphalen, Paul Hofman
The immune pathology of bursitis in rheumatic inflammatory diseases, degenerative conditions and mechanical stress: A systematic review
Published in: SEMINARS IN ARTHRITIS AND RHEUMATISM
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10.1016/j.semarthrit.2024.152527
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OBJECTIVE: To summarize current insights on the immune pathology of bursitis caused by rheumatic inflammatory diseases, degenerative conditions, or mechanical stress and identify knowledge gaps in this field. Data on tenosynovitis pathology was included for comparison. METHODS: We performed a systematic review encompassing an electronic database search of all published literatures in PubMed/MEDLINE from inception to February 13, 2023, investigating the immunological changes occurring in the bursa of patients with inflammatory rheumatic diseases, degenerative conditions or mechanical stress (e.g., impingement syndrome). RESULTS: Thirty-two articles provided data on the...
Plasma symmetric dimethylarginine and kidney graft function in kidney transplant recipients
Published in: Nephrology Dialysis Transplantation
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10.1093/ndt/gfae109
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TransplantLines Investigators, Daan Kremer, Sovia Salamah, Dion Groothof, Adrian Post, Tim J. Knobbe, António W.Gomes Neto, Sarah Peterson, Marco van Londen, Murthy Yerramilli, Stefan P. Berger, Firas F. Alkaff, Martin H. De Borst, Stephan J.L. Bakker
ELISA-4-amyloid: diagnostic accuracy of an ELISA panel for typing the four main types of systemic amyloidosis in subcutaneous abdominal fat tissue samples
Published in: Amyloid
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10.1080/13506129.2024.2385977
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BACKGROUND: Reliable typing of amyloid is essential. Amyloid extraction from tissue enables immunochemical typing of the precursor protein using an enzyme-linked immunosorbent assay (ELISA). OBJECTIVE: To assess the diagnostic accuracy of a panel of ELISAs for typing the four main types (AA, ATTR, AL-kappa and AL-lambda amyloid). METHODS: From 1996 to 2023 subcutaneous abdominal fat tissue aspirates were obtained from 1339 amyloidosis patients and 868 controls. Amyloid was visually graded 0-4+ in Congo red-stained smears. Amyloid extracted from tissue by Guanidine was typed using a panel comprising four...