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Lydia Visser

My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.

Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections
The absence of reactivity on routinely prepared tissue sections has hampered the use of monoclonal antileukocyte antibodies in diagnostic histopathology. Here we describe five new antibodies reactive with leukocyte subsets in formaldehyde-fixed, paraffin-embedded tissue sections. Antibody MT1 is reactive with mature and immature T cells and not with mature B cells. MT2 is reactive with mature T cells and B cells, but not with immature T cells, activated T cells, and germinal center B cells. Antibody MB1 is reactive with all B cells, with about 50% of mature...
Sibrand Poppema , Harry Hollema, Lydia Visser, Hans Vos
Nodular lymphocyte predominance type of Hodgkin’s disease is a germinal center lymphoma
Nodular lymphocyte predominance type of Hodgkin’s disease can be distinguished from other subtypes of Hodgkin’s disease on morphological and clinical grounds. Immunohistological studies on frozen tissue sections of seven cases of nodular lymphocyte predominance type of Hodgkin’s disease (NLPHD) show differences in B cell, T cell, as well as dendritic cell population. NLPHD is confined to follicles which contain predominantly small lymphocytes, usually over 50% B cells and large numbers of B2+, anti-C3b+, anti-DRC+, and Ig- dendritic cells. The IgM+, IgD+, Leu8- B lymphocytes are of polyclonal origin....
W Timens, L Visser, S Poppema
Morphologic, immunologic, enzymehistochemical and chromosomal analysis of a cell line derived from Hodgkin’s disease: Evidence for a B-cell origin of Sternberg-Reed cells
Published in: Cancer
Cell lines derived from Hodgkin’s disease may provide a clue to the nature of Sternberg-Reed cells. In the current study, the establishment of an Epstein-Barr-virus-negative lymphoblastoid cell line, derived from the pleural fluid of a patient with the nodular sclerosis type of Hodgkin’s disease, is described. The morphologic and immunologic cell marker findings indicate that this cell line is derived from Sternberg-Reed cells. The immunologic findings and a chromosomal analysis are in agreement with a B-lymphocyte origin of these cultured cells. Extrapolation of the results to Hodgkin’s disease...
Sibrand Poppema, Bauke de Jong, Jane Atmosoerodjo, Vera Idenburg, Lydia Visser, Lou de Ley
Double immunoenzymatic staining employing rat and mouse monoclonal antibodies
S. Poppema, A Boes, L. de Ley, T. Rozeboom, W. Timens, E. Schwander, L. Visser
Nodular lymphocyte predominance type of Hodgkin’s disease is a B cell lymphoma
S Poppema, W Timens, L Visser