Anke van den Berg
prof. dr.
I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.
MicroRNA expression patterns in precursor lesions and (hereditary) breast cancer
Liqiang Qi
Molecular genetic studies in epithelial cells of lung cancer and COPD patients
Mirjam Catharina Boelens
Classical Hodgkin lymphoma: investigation of the cross-talk between the HRS cells and the reactive lymphocytes
Hodgkin lymphoma (HL) is characterized by a minority of Hodgkin and Reed-Sternberg (HRS) cells in a polymorphous cellular background. The presence of these very abundant inflammatory cells suggest that they are not just bystander cells but interact actively with the HRS cells. Several studies indicate that immunological mechanisms and cross-talk between HRS cells and the surrounding inflammatory cells are important in the pathogenesis of HL by providing growth and anti-apoptotic signals for the HRS cells or by suppressing effective immune responses. Despite intensive research focused on this cross-talk, many of these interactions remain unclear. In this study we characterized (a) the reactive T lymphocytes in classical HL (cHL) tissue by gene expression profiling to further elucidate their phenotype and (b) the secretome of HRS cells using a proteomics approach.
Yue Ma