As a hematologist I am always looking for new development that might improve patient care. My main research focus is on patients with Hodgkin lymphoma and multiple myeloma. I am involved in both translational and clinical studies. In cooperation with the Pathology, I am active in the field of biomarkers, such as TARC in Hodgkin lymphoma. For the design, development and execution of clinical trials, I am an active member of both international (EORTC) and national (HOVON) organizations. For example, I am the national PI of the EORTC COBRA trial in Hodgkin lymphoma. Moreover, I am co-PI of the translational research in two international trials. In addition, I am part of the Dutch guideline writing committee for Hodgkin lymphoma. In myeloma, I am investigating innovative treatment options to improve outcome.
Mid-treatment TARC and mid-treatment FGD-PET predict for progression free survival in classical hodgkin lymphom
Mid-treatment TARC and mid-treatment FGD-PET predict for progression free survival in classical hodgkin lymphom
Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma
Published in: PLoS ONE
The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL. IGF-1R was overexpressed in 55% (44/80) of cHL patients. Phosphorylated IGF-1R was detectable in a minority of the IGF-1R positive tumor cells. The overall survival (OS, 98%) and 5-year progression-free survival (PFS, 93%) was significantly higher in IGF-1R positive cHL patients compared to IGF-1R negative patients (OS 83%,...
The Role of MicroRNAs in Hodgkin’s Lymphoma
Published in: MicroRNAs in Medicine
In this chapter, we summarize the current knowledge on microRNA (miRNA) expression, function and putative clinical value in Hodgkin’s lymphoma (HL). HL is the second most common lymphoma subtype, and mainly affects young adults or elderly. Malignant cells in HL are scarce, usually less than 1%, and these cells are of B-cell origin. As miRNAs are involved in almost all known biological processes, deregulation of miRNAs is thought to play an important role in the pathogenesis of HL. MiRNA expression studies have been performed on HL cell lines,...
Expression of the c-Met oncogene by tumor cells predicts a favorable outcome in classical Hodgkin’s lymphoma
Published in: Haematologica
BACKGROUND: The c-Met signaling pathway regulates a variety of biological processes, including proliferation, survival and migration. Deregulated c-Met activation has been implicated in the pathogenesis and prognosis of many human malignancies. We studied the function and prognostic significance of c-Met and hepatocyte growth factor protein expression in patients with classical Hodgkin’s lymphoma. DESIGN AND METHODS: Expression of c-Met and its ligand, hepatocyte growth factor, were determined by immunohistochemistry. Prognostic values were defined in cohorts of German and Dutch patients with classical Hodgkin’s lymphoma. Functional studies were performed on...
Chuanhui Xu,
Wouter Plattel,
Anke van den Berg, Nele Ruether, Xin Huang, Miao Wang, Debora de Jong, Hans Vos,
Gustaaf van Imhoff, Andreas Viardot, Peter Moeller, Sibrand Poppema,
Arjan Diepstra,
Lydia Visser
