Walter Noordzij
dr.
In my profession as a nuclear medicine physician, I’m involved in both clinical and scientific applications of nuclear medicine and radiology modalities. My main interests include haematology, general oncology, radio-immunotherapy, and especially the implementation of new therapeutic strategies. Currently, I have a special interest in imaging post-transplant lymphoproliferative disease, as well as radio-immunotherapy in chemotherapy refractory (non)-Hodgkin’s lymphoma.
Differential [18F]FAPI-42 and [18F]FDG uptake patterns distinguish desmoid tumours from GISTs on PET/CT imaging
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-025-07707-z
BACKGROUND: Intra-abdominal desmoid tumours (IADT) can closely mimic gastrointestinal stromal tumours (GISTs), particularly in recurrence and metastases. However, differentiating these two diseases using radiological methods remains challenging. This study aimed to investigate the value of [ 18F]FAPI-42 PET/CT in differentiating IADT and GISTs compared to [ 18F]FDG PET/CT. METHODS: This study retrospectively included a total of 24 patients (12 patients with IADT and 12 patients with recurrent/metastatic GISTs) who underwent two separate PET/CT scans using [ 18F]FAPI-42 and [ 18F]FDG, respectively. The differences in tumour SUV max on...
Chunhui Wu, Xiaoyan Wang, Xiaojie Lin, Andor W J M Glaudemans, Bart Cornelissen, Walter Noordzij, Xin Hu, Yu Zeng, Xiangsong Zhang, Xinhua Zhang
Bridging the gaps in fibroblast activation protein targeted radionuclide therapy: a translational perspective
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-025-07711-3
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Fibroblast activation protein-targeted radionuclide therapy (FAP-TRT) has emerged as a novel strategy for modulating the tumour microenvironment (TME) by selectively eradicating FAP-expressing cancer-associated fibroblasts (CAFs). Although preclinical studies have demonstrated promising results across various tumour models using diverse radiolabelled FAP inhibitors, clinical translation remains limited by modest efficacy, short tumour retention, and highly heterogeneousresponses. This review aims to provide an overview of recent advances in radiopharmaceutical design to enhance tumour targeting and prolong retention. Furthermore, we summarise early clinical findings and ongoing trials, while emphasising the potential translational...
Exploratory Evaluation of the Predictive Value of Serum Neurofilament Light Chain for Autonomic Neuropathy in Hereditary Transthyretin Amyloidosis
Published in: Journal of Clinical Medicine
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10.3390/jcm15051862
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Background/Objectives: Serum neurofilament light chain (sNfL) is a biomarker for peripheral neuropathy as sNfL correlates with polyneuropathy severity in hereditary transthyretin (ATTRv) amyloidosis. It is unclear whether sNfL also correlates with autonomic neuropathy (ANP). In this exploratory study, we aimed to evaluate the value of sNfL as marker for ANP in patients with ATTRv amyloidosis. Methods: sNfL was measured retrospectively in 10 pathogenic transthyretin gene variant ( TTRv) carriers and 28 patients with ATTRv amyloidosis. All 38 individuals underwent a comprehensive evaluation for ANP. Results: Individuals with ANP...
Milou Berends, Anne Floor Brunger, Hendrea S A Tingen, Johan Bijzet, Charlotte E Teunissen, Paul A van der Zwaag, Reinold O B Gans, Bouke P C Hazenberg, Fiete Lange, Gea Drost, Walter Noordzij, Hans L A Nienhuis, Riemer H J A Slart
Author Correction: Whole-body CD8+ T-cell PET imaging in patients with large B-cell lymphoma before and during CD19-directed CAR T-cell therapy: a phase 2 study.
Published in: Nature Communications
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10.1038/s41467-026-69473-2
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Janneke W de Boer, Kylie Keijzer, Jaap A van Doesum, Nienke A M Smit, Adrienne H Brouwers, Joyce van Sluis, Marjolijn N Lub-de Hooge, Frank R Pierik, Gerwin A Huls, Lisanne V van Dijk, Lydia Visser, Arjan Diepstra, Walter Noordzij, Simon P Williams, Alexander Ungewickell, Sjoerd G Elias, Elisabeth G E de Vries, Anne G H Niezink, Tom van Meerten
Separation of simultaneously acquired [89Zr]atezolizumab and [18F]FDG PET scans
Published in: European Journal of Nuclear Medicine and Molecular Imaging
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10.1007/s00259-025-07340-w
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