Marcel Nijland
dr.
I work as a hematologist and my main focus is on patients with aggressive B-cell lymphomas and CNS lymphomas. My research is centered on the application of novel diagnostic and therapeutic strategies into clinical trials. These include imaging-studies like 18F-FDG-PET, Zr-Brentuximab-PET and Zr-atezolizumab-PET. In addition, I aim to implement novel strategies to measure minimal residual disease, and prognostic gene expression profiles in DLBCL. Linked to this I also focus on mutational analysis to study clonal evolution and prognostic / predictive values of mutations. These studies are carried out in a close collaboration with HOVON and other departments in the UMCG.
Non-inferior outcome of abbreviated R-CHOP in patients with stage I primary testicular lymphoma
Published in: European Journal of Cancer
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10.1016/j.ejca.2025.115776
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BACKGROUND: Patients with limited-stage primary testicular lymphoma (PTL) typically receive a multimodal regimen, including 6 cycles of R-CHOP, despite limited evidence. In low-risk diffuse large B-cell lymphoma, de-escalation to 4 R-CHOP cycles has proven non-inferior. It remains unclear whether similar de-escalation is feasible in PTL. METHODS: Patients aged ≥ 18 years with Ann Arbor stage I-II PTL diagnosed between 2014 and 2021 were identified in the Netherlands Cancer Registry. Patients receiving ≥ 3 R-CHOP cycles were included. Outcomes were 5-year progression-free survival (PFS), overall survival (OS), and cumulative incidence function...
Diana Al-Sarayfi, Johanna A A Bult, Ruben A L de Groen, Fleur A de Groot, Joost S P Vermaat, Djamilla Issa, Arjan Diepstra, Gerwin Huls, Mar Bellido, Wouter Plattel, Mirian Brink, Marcel Nijland
Serum TARC: a biomarker for early detection or exclusion of relapse in classic Hodgkin Lymphoma
Published in: Blood Advances
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10.1182/bloodadvances.2025015837
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Relapsed and refractory peripheral T-cell lymphoma; treatment, challenges and future perspectives
Published in: Leukemia & lymphoma
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10.1080/10428194.2025.2545927
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Peripheral T-cell lymphomas (PTCL) comprise a heterogeneous group of 15 different neoplasms in adults. In Europe and North America, PTCL not otherwise specified (PTCL NOS), nodal T follicular helper lymphoma, angioimmunoblastic type (nTFHL-AI), and anaplastic large cell lymphoma (ALCL) either anaplastic lymphoma kinase (ALK) positive (+) or negative (-) are the most prevalent PTCLs. Relapsed or refractory disease (R/R) is common in PTCL and its management is challenging. Despite response rates and prognoses being disease specific, the outcome of R/R PTCL is dismal except for R/R ALK+ ALCL....
Frederik O Meeuwes, Yasmina I M Serroukh, Marjolein W M van der Poel, Wouter J Plattel, Marcel Nijland
Treatment and outcome of breast implant-associated anaplastic large cell lymphoma: a population-based cohort study in the Netherlands
Published in: Leukemia & lymphoma
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10.1080/10428194.2025.2530167
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The optimal treatment of patients with breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) that underwent incomplete resection, have advanced stage disease or relapse after resection remains unknown. We describe the treatment and outcome of all 91 Dutch BIA-ALCL patients up to 2023. Primary outcomes were progression-free survival (PFS) and overall survival (OS). Ann Arbor stage I was frequently encountered (74%) compared to stage II (13%) and stage IV (11%). First-line treatment of stage I patients consisted mostly of surgery (88%). Stage II patients were treated with chemotherapy (CT)...
Frederik O Meeuwes, Mirian Brink, Marjolein W M van der Poel, Y I M Serroukh, Joost S P Vermaat, Gerwin A Huls, Mintsje de Boer, Daphne de Jong, Wouter J Plattel, Marcel Nijland
MATRix and HD-MTX/IFO/DEP treatment and autologous stem cell transplantation in secondary central nervous system lymphoma: a Dutch retrospective analysis
Published in: Haematologica
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10.3324/haematol.2025.287485
Fleur A De Groot, Floriske G Stedema, Esther J Kret, Lorraine M De Haan, Patty M Jansen, Stefan Böhringer, Arjan Diepstra, Marjolein W M Van der Poel, Myrurgia Abdul Hamid, Liane C J Te Boome, Valeska Terpstra, Mirian Brink, Hendrik Veelken, Ruben A L De Groen, Tim J A Dekker, Marcel Nijland, Joost S P Vermaat