Marcel Nijland
dr.
I work as a hematologist and my main focus is on patients with aggressive B-cell lymphomas and CNS lymphomas. My research is centered on the application of novel diagnostic and therapeutic strategies into clinical trials. These include imaging-studies like 18F-FDG-PET, Zr-Brentuximab-PET and Zr-atezolizumab-PET. In addition, I aim to implement novel strategies to measure minimal residual disease, and prognostic gene expression profiles in DLBCL. Linked to this I also focus on mutational analysis to study clonal evolution and prognostic / predictive values of mutations. These studies are carried out in a close collaboration with HOVON and other departments in the UMCG.
Proteomics Based Identification of Proteins with Deregulated Expression in B Cell Lymphomas
Published in: PLoS ONE
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10.1371/journal.pone.0146624
document
Follicular lymphoma and diffuse large B cell lymphomas comprise the main entities of adult B cell malignancies. Although multiple disease driving gene aberrations have been identified by gene expression and genomic studies, only a few studies focused at the protein level. We applied 2 dimensional gel electrophoresis to compare seven GC B cell non Hodgkin lymphoma (NHL) cell lines with a lymphoblastoid cell line (LCL). An average of 130 spots were at least two folds different in intensity between NHL cell lines and the LCL. We selected approximately...
Rui Wu, Marcel Nijland, Bea Rutgers, Rianne Veenstra, Myra Langendonk, Lotte E. van der Meeren, Philip M. Kluin, Guanwu Li, Arjan Diepstra, Jen-Fu Chiu, Anke van den Berg, Lydia Visser
The mutational landscape of Hodgkin lymphoma cell lines determined by whole-exome sequencing
Published in: Leukemia
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10.1038/leu.2014.201
Y. Liu, F.R. Abdul Razak, M. Terpstra, F.C. Chan, A. Saber, M. Nijland, G. van Imhoff, Lydia Visser, R. Gascoyne, C. Steidl, J. Kluiver, A. Diepstra, K. Kok, Anke van den Berg
False positive spinal cord uptake on fluorodeoxyglucose positron-emission tomography following treatment of lymphoma
Published in: British Journal of Haematology
Access to document
10.1111/bjh.12057
Marcel Nijland, Max Beijert, Alfons H. H. Bongaerts, Adrienne H. Brouwers
Adrenal Hemorrhage Causing Adrenal Insufficiency in a Patient with Antiphospholipid Syndrome: Increased Adrenal F-18-FDG Uptake
Published in: Journal of Clinical Endocrinology and Metabolism
Access to document
10.1210/jc.2012-2050
Leo Boneschansker, Marcel Nijland, Andor W J M Glaudemans, Sibylle B van der Meulen, Philip M Kluin, Robin P F Dullaart