Lydia Visser
PhD
My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.
Postnatal changes of CD45 expression in peripheral blood T and B cells
One known postnatal change of CD45 expression is the decline of the CD45RA(high) CD45RO(low) T subsets and the reciprocal increase of the CD45RA(low) CD45RO(high) T subsets in the peripheral blood. Using a panel of monoclonal antibodies reactive with either protein or carbohydrate epitopes on the variable regions of CD45, we were able to detect more postnatal changes of CD45 expression. These changes are largely caused by modulation of the CD45 glycosylation, including: (1) lesser sialylation of the CD45RA region on T cells, and (2) differential sialylation of the...
R LAI, Lydia Visser, S POPPEMA
Postnatal changes of CD45 expression in peripheral blood T and B cells
One known postnatal change of CD45 expression is the decline of the CD45RA(high) CD45RO(low) T subsets and the reciprocal increase of the CD45RA(low) CD45RO(high) T subsets in the peripheral blood. Using a panel of monoclonal antibodies reactive with either protein or carbohydrate epitopes on the variable regions of CD45, we were able to detect more postnatal changes of CD45 expression. These changes are largely caused by modulation of the CD45 glycosylation, including: (1) lesser sialylation of the CD45RA region on T cells, and (2) differential sialylation of the...
R LAI, Lydia Visser, S POPPEMA