Lydia Visser
PhD
My research in the Pathology department is mainly focused on immunological aspects of B-cell lymphoma. I study interactions of tumor cells with the microenvironment, and signaling pathways in Hodgkin lymphoma and non-Hodgkin lymphomas.
In vitro system for evaluation of the immunomodulatory capacity of CD45(R) reagents
S Poppema, L Visser, X Y Jiang
In vitro system for evaluation of the immunomodulatory capacity of CD45(R) reagents
S Poppema, L Visser, X Y Jiang
CD45 (leucocyte common antigen) expression in T and B lymphocyte subsets
Published in: Leukemia and Lymphoma
Access to document
10.3109/10428199609051610
CD45 is the dominant tyrosine phosphatase in haematopoietic cells and can modulate the effects of many other signaling molecules by dephosphorylation. The extracellular portion of CD45 has considerable variability due to differential splicing and glycosylation. This may allow for interactions with a variety of ligands expressed on interacting cells or on the same cell surface. Monoclonal anti CD45 antibodies that are reactive with epitopes that result from differential splicing and glycosylation can distinguish between cell populations that differ in maturation and function. These reagents can be used in...
S Poppema, R Lai, L Visser, X J Yan
Immunophenotype and functional characteristics of T cells in Hodgkin’s disease
S Poppema, Lydia Visser
Immunophenotype and functional characteristics of T cells in Hodgkin’s disease
S Poppema, Lydia Visser