Joost Kluiver
dr.
I have a central role in all research projects focusing on the role of noncoding RNAs. My main aim is to understanding how small and long non-coding RNAs contribute to the pathogenesis of B-cell lymphoma. Ongoing studies include MYC-regulated miRNAs and lncRNAs, as well as miRNA-lncRNA interactions and the role of circular RNAs. We apply state-of-the-art methodology including AGO2-RIP, RNA-FISH and gain- and loss-of-function screens using shRNA and CRISPR-Cas technology.
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High expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma
Published in: Journal of Clinical Pathology
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10.1136/jcp.2004.022335
Aim: To gain more insight into the genes involved in the aetiology and pathogenesis of anaplastic large cell lymphoma (ALCL). Methods: Serial analysis of gene expression ( SAGE) was undertaken on the CD4+ALK+ ( anaplastic lymphoma kinase positive) ALCL derived cell line Karpas299 and as comparison on CD4+ T cells. Quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry were performed on five ALCL derived cell lines and 32 tissue samples to confirm the SAGE data. Results: High expression of Mcl-1 was seen in the Karpas299 cell line,...
R Rust, G Harms, T Blokzijl, M Boot, A Diepstra, J Kluiver, L Visser, SC Peh, M Lim, WA Kamps, S Poppema, Anke van den Berg
High expression of B-cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma
Published in: Genes Chromosomes & Cancer
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10.1002/gcc.10186
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Anke van den Berg, Bart-Jan Kroesen, K. Kooistra, Doetje de Jong, J. Briggs, T. Blokzijl, S. Jacobs, J. Kluiver, Arjan Diepstra, Ewerton Maggio, Sibrand Poppema
Common and differential chemokine expression patterns in RS cells of NLP, EBV positive and negative classical Hodgkin lymphomas
Published in: International Journal of Cancer
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10.1002/ijc.10399
Hodgkin lymphoma (HL) is characterized by a minority of neoplastic cells, the so-called Reed-Sternberg (RS) cells and a vast majority of reactive cells. RS cells produce chemokines that can attract subsets of peripheral blood cells into HL tissues. To gain insight in the chemokines involved in HL, 16 chemokines were selected based on their ability to recruit different subsets of cells. Five HL, 5 non-HL-derived cell lines, 22 HL, 5 non-HL and 3 control tissues were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). Products for 13 of these...
Chemokines, cytokines and their receptors in Hodgkin’s lymphoma cell lines and tissues
Background: Hodgkin’s lymphoma (HL) is characterized by a minority of neoplastic cells, the so-called Reed-Sternberg (RS) cells, and an admixture of reactive cells including lymphocytes, plasma cells, eosinophils and histiocytes. Cytokines produced in HL, either by RS or infiltrating cells, might explain the presence and maintenance of an impaired immune response, Chemokines (cytokines with chemoattractant properties) produced by RS cells play a major role in leukocyte trafficking. These molecules with specific receptor affinities contribute, for example by attracting TH2-like T cells, to the maintenance of a favorable environment...