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Arjan Diepstra
dr.

As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.

High expression of Mcl-1 in ALK positive and negative anaplastic large cell lymphoma
Published in: Journal of Clinical Pathology
Access to document 10.1136/jcp.2004.022335
Aim: To gain more insight into the genes involved in the aetiology and pathogenesis of anaplastic large cell lymphoma (ALCL). Methods: Serial analysis of gene expression ( SAGE) was undertaken on the CD4+ALK+ ( anaplastic lymphoma kinase positive) ALCL derived cell line Karpas299 and as comparison on CD4+ T cells. Quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemistry were performed on five ALCL derived cell lines and 32 tissue samples to confirm the SAGE data. Results: High expression of Mcl-1 was seen in the Karpas299 cell line,...
R Rust, G Harms, T Blokzijl, M Boot, A Diepstra, J Kluiver, L Visser, SC Peh, M Lim, WA Kamps, S Poppema, Anke van den Berg
High expression of B-cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma
Published in: Genes Chromosomes & Cancer
Access to document 10.1002/gcc.10186 document
Anke van den Berg, Bart-Jan Kroesen, K. Kooistra, Doetje de Jong, J. Briggs, T. Blokzijl, S. Jacobs, J. Kluiver, Arjan Diepstra, Ewerton Maggio, Sibrand Poppema
Low frequency of FAS mutations in Reed-Sternberg cells of Hodgkin’s lymphoma
Ewerton Maggio, Anke van den Berg, Doetje de Jong, Arjan Diepstra, Sibrand Poppema
Low frequency of FAS mutations in Reed-Sternberg cells of Hodgkin’s lymphoma
Ewerton Maggio, Anke van den Berg, Doetje de Jong, Arjan Diepstra, Sibrand Poppema
Clonal relation in a case of CLL, ALCL, and Hodgkin composite lymphoma
Large cell lymphomas and Hodgkin disease may develop during the course of chronic lymphocytic leukemia (CLL). In some cases the transformed cells are Epstein-Barr virus (EBV)-positive and not clonally related to the CLL cells. In other cases the transformed cells have the same clonal rearrangements as the CLL cells. Here we describe a composite lymphoma in a patient with CLL that exhibits a combination of CLL/small lymphocyte lymphoma, large cell lymphoma with anaplastic morphology, and Hodgkin lymphoma (HL). Although the large cell lymphoma cells are CD45R0 and TIA-1-positive,...
Anke van den Berg, Ewerton Maggio, R Rust, K Kooistra, A Diepstra, S Poppema