Arjan Diepstra
dr.
As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.
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A genome-wide association study of Hodgkin’s lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
Published in: Nature Genetics
Access to document
10.1038/ng.696
To identify susceptibility loci for classical Hodgkin’s lymphoma (cHL), we conducted a genome-wide association study of 589 individuals with cHL (cases) and 5,199 controls with validation in four independent samples totaling 2,057 cases and 3,416 controls. We identified three new susceptibility loci at 2p16.1 (rs1432295, REL, odds ratio (OR) = 1.22, combined P = 1.91 x 10(-8)), 8q24.21 (rs2019960, PVT1, OR = 1.33, combined P = 1.26 x 10(-13)) and 10p14 (rs501764, GATA3, OR = 1.25, combined P = 7.05 x 10(-8)). Furthermore, we confirmed the role of...
Victor Enciso-Mora, Peter Broderick, Yussanne Ma, Ruth F. Jarrett, Henrik Hjalgrim, Kari Hemminki, Anke van den Berg, Bianca Olver, Amy Lloyd, Sara E. Dobbins, Tracy Lightfoot, Flora E. van Leeuwen, Asta Foersti, Arjan Diepstra, Annegien Broeks, Jayaram Vijayakrishnan, Lesley Shield, Annette Lake, Dorothy Montgomery, Eve RomanAndreas Engert, Elke Pogge von Strandmann, Katrin S. Reiners, Ilja M. Nolte, Karin E. Smedby, Hans-Olov Adami, Nicola S. Russell, Bengt Glimelius, Stephen Hamilton-Dutoit, Marieke de Bruin, Lars P. Ryder, Daniel Molin, Karina Meden Sorensen, Ellen T. Chang, Malcolm Taylor, Rosie Cooke, Robert Hofstra, Helga Westers, Tom van Wezel, Ronald van Eijk, Alan Ashworth, Klaus Rostgaard, Mads Melbye, Anthony J. Swerdlow, Richard S. Houlston
EXPRESSION OF THE C-MET ONCOGENE CORRELATES WITH FAVORABLE PROGRESSION FREE SURVIVAL IN CLASSICAL HODGKIN LYMPHOMA
C. Xu, A. van den Berg, W. Plattel, N. Ruether, X. Huang, M. Wang, D. de Jong, H. Vos, G. van Imhoff, A. Viardot, P. Moeller, S. Poppema, A. Diepstra, L. Visser
PROSPECTIVE ANALYSIS OF PLASMA LEVELS OF THYMUS AND ACTIVATION REGULATED CHEMOKINE (TARC) IN PRIMARY AND RELAPSED CLASSICAL HODGKIN LYMPHOMA PATIENTS
W. Plattel, A. van den Berg, A. M. Van der Graaf, S. Poppema, L. Visser, A. Diepstra, G. W. Van Imhoff
EXPRESSION AND FUNCTION OF TOLL LIKE RECEPTORS TLR4, TLR7 AND TLR9 IN CLASSICAL HODGKIN LYMPHOMA
C. Xu, L. Visser, A. Diepstra, P. Moeller, S. Poppema, A. van den Berg
HLA EXPRESSION AND GENETIC ASSOCIATIONS IN EBV POSITIVE AND EBV NEGATIVE CLASSICAL HODGKIN LYMPHOMA
A. Diepstra, B. Hepkema, H. Xin, C. Xu, K. Kushekhar, R.J.M. Nolte, L. Visser, S. Poppema, A. van den Berg