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Arjan Diepstra
dr.

As a hematopathologist, I work on diagnostics of all types of hematological malignancies using a comprehensive panel of different techniques. Moreover, my main research interest involves Hodgkin lymphoma, with a strong focus on interactions between tumor cells and the microenvironment. In addition, I also have a long standing interest in genetic susceptibility. My areas of expertise are: immunology, tumor cell biology, genetic association studies and molecular diagnostics in pathology. I actively participate in international (EORTC) and national (HOVON) clinical trials.

Demographics and additional haematologic cancers of patients with histiocytic/dendritic cell neoplasms
Published in: Histopathology
Access to document 10.1111/his.15127 document
AIMS: The discovery of somatic genetic alterations established many histiocytic disorders as haematologic neoplasms. We aimed to investigate the demographic characteristics and additional haematologic cancers of patients diagnosed with histiocytic disorders in The Netherlands. METHODS AND RESULTS: We retrieved data on histiocytosis patients from the Dutch Nationwide Pathology Databank (Palga). During 1993 to 2022, more than 4000 patients with a pathologist-assigned diagnosis of a histiocytic disorder were registered in Palga. Xanthogranulomas were the most common subtype, challenging the prevailing assumption that Langerhans cell histiocytosis (LCH) is the most...
Paul G Kemps, Lennart Kester, Marijn A Scheijde-Vermeulen, Carel J M van Noesel, Robert M Verdijk, Arjan Diepstra, Ariënne M W van Marion, Natasja Dors, Cor van den Bos, Annette H Bruggink, Pancras C W Hogendoorn, Astrid G S van Halteren
Pinpointing Functionally Relevant miRNAs in Classical Hodgkin Lymphoma Pathogenesis
Published in: Cancers
Access to document 10.3390/cancers16061126 document
Classical Hodgkin lymphoma (cHL) is a hematological malignancy of B-cell origin. The tumor cells in cHL are referred to as Hodgkin and Reed-Sternberg (HRS) cells. This review provides an overview of the currently known miRNA-target gene interactions. In addition, we pinpointed other potential regulatory roles of microRNAs (miRNAs) by focusing on genes related to processes relevant for cHL pathogenesis, i.e., loss of B-cell phenotypes, immune evasion, and growth support. A cHL-specific miRNA signature was generated based on the available profiling studies. The interactions relevant for cHL were extracted...
Yujia Pan, Roza Cengiz, Joost Kluiver, Arjan Diepstra, Anke Van den Berg
TOX as a new diagnostic marker for T cell large granular lymphocytic leukaemia
Published in: Histopathology
Access to document 10.1111/his.15114 document
AIMS: T cell large granular lymphocytic leukaemia (T-LGLL) is a rare disorder that may underlie otherwise unexplained cytopenias. The identification of T-LGLL cells in bone marrow biopsies can be a challenge, because a robust immunohistochemistry marker is lacking. The markers currently in use (granzyme B, TIA-1 and CD8) are difficult to interpret or lack specificity. Therefore, we investigated whether immunohistochemistry for thymocyte selection-associated high-mobility group box (TOX), a transcription factor that associates with chronic T cell stimulation, could be a reliable tool for the identification of T-LGLL cells....
Manske M L Burg, Lydia Visser, Arjan Diepstra
Clonal hematopoiesis and UBA1 mutations in individuals with biopsy-proven giant cell arteritis and population-based controls
Published in: Rheumatology
Access to document 10.1093/rheumatology/kead435 document
Jonas B Salzbrunn, Isabelle A van Zeventer, Aniek O de Graaf, Priscilla Kamphuis, Maaike G J M van Bergen, Yannick van Sleen, Bert A van der Reijden, Jan Jacob Schuringa, Elisabeth Brouwer, Arjan Diepstra, Joop H Jansen, Gerwin Huls
Inhibition of the glutamate-cysteine ligase catalytic subunit with buthionine sulfoximine enhances the cytotoxic effect of doxorubicin and cyclophosphamide in Burkitt lymphoma cells
Published in: Journal of Applied Genetics
Access to document 10.1007/s13353-023-00797-1 document
Burkitt lymphoma (BL) is a highly aggressive lymphoma that mainly affects children and young adults. Chemotherapy is effective in young BL patients but the outcome in adults is less satisfactory. Therefore, there is a need to enhance the cytotoxic effect of drugs used in BL treatment. Glutathione (GSH) is an important antioxidant involved in processes such as regulation of oxidative stress and drug detoxification. Elevated GSH levels have been observed in many cancers and were associated with chemoresistance. We previously identified GCLC, encoding an enzyme involved in GSH...
Marta Kazimierska, Aleksandra Leśniewska, Anja Bakker, Arjan Diepstra, Marta Elżbieta Kasprzyk, Marta Podralska, Karolina Rassek, Joost Kluiver, Anke van den Berg, Natalia Rozwadowska, Agnieszka Dzikiewicz-Krawczyk