Anke van den Berg
prof. dr.
I work as a clinical molecular biologist in the department of Pathology. In this function I supervise and implement advanced molecular diagnostic techniques. Within my research line, I focus on the molecular pathogenesis of B-cell Hodgkin and non-Hodgkin lymphoma. The specific fields of interest are genomic aberrations, genetic susceptibility, and the role of small and long noncoding RNAs. I have several international collaborations and am PI and co-PI in various projects.
Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma
Published in: Oncotarget
Access to document
10.18632/oncotarget.6165
document
Several studies have indicated an important role for miR-155 in the pathogenesis of B-cell lymphoma. Highly elevated levels of miR-155 were indeed observed in most B-cell lymphomas with the exception of Burkitt lymphoma (BL). However, the molecular mechanisms that underlie the oncogenic role of miR-155 in B-cell lymphoma are not well understood. To identify the miR-155 targets relevant for B-cell lymphoma, we performed RNA immunoprecipitation of Argonaute 2 in Hodgkin lymphoma (HL) cells upon miR-155 inhibition and in BL cells upon ectopic expression of miR-155. We identified 54...
Joost Kluiver, Izabella Slezak-Prochazka, Debora de Jong, Katarzyna Smigielska, Gertrud Kortman, Melanie Winkle, Bea Rutgers, Jasper Koerts, Lydia Visser, Arjan Diepstra, Bart-Jan Kroesen, Anke van den Berg
Proteomics Based Identification of Proteins with Deregulated Expression in B Cell Lymphomas
Published in: PLoS ONE
Access to document
10.1371/journal.pone.0146624
document
Follicular lymphoma and diffuse large B cell lymphomas comprise the main entities of adult B cell malignancies. Although multiple disease driving gene aberrations have been identified by gene expression and genomic studies, only a few studies focused at the protein level. We applied 2 dimensional gel electrophoresis to compare seven GC B cell non Hodgkin lymphoma (NHL) cell lines with a lymphoblastoid cell line (LCL). An average of 130 spots were at least two folds different in intensity between NHL cell lines and the LCL. We selected approximately...
Rui Wu, Marcel Nijland, Bea Rutgers, Rianne Veenstra, Myra Langendonk, Lotte E. van der Meeren, Philip M. Kluin, Guanwu Li, Arjan Diepstra, Jen-Fu Chiu, Anke van den Berg, Lydia Visser
Transforming Growth Factor Beta Affects Mirna Expression In Control And COPD Fibroblasts
J. Ong, W. Timens, V. Rajendran, A. Algra, A. Spira, M. Lenburg, J. Campbell, D. S. Postma, A. Van den Berg, J. Kluiver, Corry-Anke Brandsma
Impact of Radiotherapy and Rituximab on Outcome of Stage I(E) Diffuse Large B-Cell Lymphoma
Marcel Nijland, Karin Boslooper, Anke Van den Berg, Hanneke C. Kluin-Nelemans, Peter Joosten, Huib Storm, Robby Kibbelaar, Gustaaf van Imhoff, Mels Hoogendoorn
Mutations in CD58 and Other Immune System Related Genes in Hodgkin Lymphoma