Andor Glaudemans
prof. dr.
I am a nuclear medicine specialist and always trying to implement innovative diagnostic and therapeutic methods in imaging. My main research interests involve infectious and inflammatory diseases, tumor-immunology, and development of new-targeted diagnostic tools for PET imaging. The latter focus is carried out in close collaboration with our radiochemists. Within the lymphoma research Groningen team we have a close collaboration with the department of hematology. The research is focused on finding new methods for diagnosis and therapy evaluation in several types of lymphomas. We have a special interest in post-transplant lymphatic disorders (PTLD). Furthermore, we are developing and evaluating several fields of radionuclide therapy, so called theranostics.
[18F]FDG PET/CT identifies infectious and inflammatory foci in persistent critical illness
Published in: Annals of Intensive Care
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10.1186/s13613-025-01444-0
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Purpose: Some ICU patients remain critically ill despite reversal of the original admission diagnosis, driven by a cascade of events resulting in new and persistent organ failure. Secondary infections and systemic inflammation are important components of this cascade and may be visualised using [18F]FDG PET/CT. The aim of this dual centre retrospective study was to assess the ability of [18F]FDG PET/CT to identify infectious and inflammatory foci in patients with persistent critical illness and to evaluate its impact on subsequent therapy management. Methods: We included patients admitted to...
Bram van Leer, Jelle L.G. Haitsma Mulier, Cornelis P. van Stee, Kiki M. Demenaga, Riemer H.J.A. Slart, Matijs van Meurs, Andor W.J.M. Glaudemans, Maarten W.N. Nijsten, Lennie P.G. Derde, Janesh Pillay
Multispectral optoacoustic tomography of salivary glands in patients with clinically suspected Sjögren’s disease: A pilot study
Published in: Photoacoustics
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10.1016/j.pacs.2025.100778
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Sjögren’s disease (SjD) is a systemic auto-immune disease characterized by salivary gland inflammation and glandular dysfunction. Diagnosis is challenging due to its heterogeneity and currently relies on a variety of tests that are present in the ACR-EULAR classification criteria. These include invasive and resource-intensive tests, highlighting the unmet need for a single, accurate, non-invasive diagnostic modality. Multispectral optoacoustic tomography (MSOT), enabling functional imaging of hemoglobin-related parameters, may address this gap. This pilot study evaluates MSOT’s potential for salivary gland imaging in patients suspected of SjD. This study included...
Rik de Jong, Milou E. Noltes, Hendrika Bootsma, Gooitzen M. van Dam, Andor W.J.M. Glaudemans, Schelto Kruijff, Riemer H.J.A. Slart, Alja Stel, Max J.H. Witjes, Konstantina Delli, Jasper Vonk
Comparative analysis of FES-PET/CT and FDG-PET/CT in patients with ER-positive metastatic invasive lobular breast cancer
Published in: European Journal of Cancer
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10.1016/j.ejca.2025.115792
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BACKGROUND: Detection of metastatic invasive lobular carcinoma (mILC) with standard imaging is challenging. 2-[18F]Fluoro-2-deoxyglucose (FDG) PET/CT is commonly used in the work-up of metastatic breast cancer (MBC), but may be suboptimal for mILC. 16α-[18F]Fluoro-17β-estradiol (FES) PET/CT measures estrogen receptor (ER) expression, which is generally high in mILC. To assess whether FES-PET/CT outperforms FDG-PET/CT, we compared the detection rate of both scans to identify mILC, in patients who were enrolled in the prospective IMPACT-MBC study. METHODS: Patients with newly diagnosed ER-positive mILC underwent baseline FDG-PET/CT, FES-PET/CT, diagnostic computed tomography...
IMPACT-Metastatic Breast Consortium, Jasmine Moustaquim, Gabriëlle E van Wonderen, Jasper J L van Geel, Michel van Kruchten, Erik F J de Vries, Agnes Jager, Evelien Kuip, Marcel P M Stokkel, Andor W J M Glaudemans, Adrienne H Brouwers, Geke A P Hospers, C Willemien Menke-van der Houven van Oordt, Bert van der Vegt, Elisabeth G E de Vries, Carolina P Schröder
Influence of Ultra-Low-Dose CT on PET Image Quantification and Visual Assessment
Published in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
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10.2967/jnumed.124.269188
Recent advances in high-sensitivity PET allow for significantly reduced radiation doses, making the CT radiation dose a larger fraction of the total scan dose. This is the first study to the best of our knowledge that evaluates the feasibility and efficacy of an ultra-low-dose CT (ULD-CT) protocol, incorporating a Sn filter, by reducing radiation exposure while maintaining PET image quality and quantitative accuracy in oncology patients. Methods: The study involved 29 oncology patients. FDG PET/CT scans were performed using both low-dose CT (LD-CT) and ULD-CT protocols. The ULD-CT...
Impact of Ultrahigh Sensitivity and Continuous Bed Motion on Performance Characteristics of Biograph Vision Quadra PET/CT
Published in: Journal of Nuclear Medicine
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10.2967/jnumed.125.270078
Continuous bed motion (CBM) for long-axial-field-of-view PET/CT enables swift total-body examination of patients. However, the sensitivity profile along the axial field of view (AFOV) varies significantly, and its effect on image quality when combined with CBM remains unexplored. This study assesses the effects of ultrahigh sensitivity (UHS) and CBM on recovery coefficients (RCs) and spatial resolution (SR). Methods: Phantom measurements, performed in static bed and CBM acquisition with different bed speeds (3.5, 7, 14, and 30 mm/s), were reconstructed for both high-sensitivity (HS) and UHS modes, and their...